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The letter which will formally begin the UK's exit from the EU has been signed by the prime minister. It will be hand-delivered to Brussels this lunchtime - triggering Article 50. Negotiations for the exit deal will then be able to start. To discuss what will happen over the next 48 hours, Georgie Frost was joined by Billy Bambrough, Editor of economics and business website Verdict.co.uk.

Nigel Cassidy joined Georgie Frost to discuss the main market headlines of the morning, starting with the news of today, which is all about Article 50 being triggered. Ryanair has had its say on this. They've said aviation should be prioritised in the Brexit talks. We've also heard full-year figures from Saga, the over 50s insurance specialist. Plus we've also had trading updates from Tui and StageCoach.

A big legal defeat has driven Uber out of Denmark. A new law requires all taxis to have expensive seat sensors, meters, and video surveillance, meaning Uber is an "illegal taxi service" and not a "ride sharing app" as it claims. The ride-hailing company says it's closing it's business from mid-April. Matt Cox spoke to Paul Henty, Partner and competition law expert at law firm Charles Russell-Speechlys.

Truckman, the West Midlands-based automotive manufacturer, has made a sharp U-turn on its stance on Brexit. The company was firmly anti-Brexit and has now become a supporter of leaving the EU and has set it's sights on doubling its export activity by targeting countries including Belgium, France, Germany, the Netherlands, Luxembourg and Sweden. Chairman Mike Wheeler joined Nigel Cassidy to discuss the change of heart.

Theresa May will trigger Article 50 later. There'll be much scrutinising of the text of hints about where the coming negotiations are going, both in Brussels and London. The tone and the contents will form the basis for the EU's response. Joining Nigel Cassidy is Chris Bailey, Founder of Financial Orbit.

The pharmacy industry is trying to assess the likely impact of a £128 million government move to stop GPs writing prescriptions for 'low-priority' items. You could soon be stopped from getting travel jabs, gluten-free foods and omega-3 supplements on the NHS. You may have heard it confirmed yesterday that 10 treatments are involved in the first round of the shake-up by NHS England chief executive Simon Stevens. What difference will this make? Galen Rosenberg, owner of the Maple Leaf Pharmacy spoke to Nigel Cassidy to discuss this further.

Theresa May's letter signalling our EU exit will be delivered in around 4 hours in Brussels firing the starting gun on the UK's formal exit negotiations. Despite May's positivity, many will be asking 'what does this mean for me?', including investors. Joining Nigel Cassidy to discuss what investor's might look forward to over the next couple of years is Richard Stone, CEO of The Share Centre.

It's time to talk politics. Today: the Scottish parliament has backed a second independence referendum; direct rule in Northern Ireland looms; what do MEPs think about Brexit on the eve of Article 50?

On today's Wrap: Tesco has agreed to pay a fine of £129m to avoid prosecution for overstating its profits in 2014; Redrow has withdrawn its takeover offer for Bovis Homes; and tourists are beginning to return to terror-hit countries, such as Egypt and Turkey.

Emerging Opportunities is the only show on your radio dedicated to global emerging markets. Today: how do you get providers to take up Africa's growing supply of renewables.